Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
Silymarin positively influences cholesterol
We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.
Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.
However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.
Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.
However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.
Read More
8
Silybum marianum reduces cholesterol effectively
We explored the impacts of Silybum marianum extract on broiler chickens’ health and performance. Chicks were divided into groups, with some receiving the extract in their diet while others did not.
Interestingly, we found that the group fed with Silybum marianum showed significant benefits, including lower cholesterol levels and better weight gain. However, the method of in ovo feeding did not show any notable effects on hatchability or initial weight.
Overall, incorporating Silybum marianum in their diet appears to help improve cholesterol levels and support overall growth in chickens.
Interestingly, we found that the group fed with Silybum marianum showed significant benefits, including lower cholesterol levels and better weight gain. However, the method of in ovo feeding did not show any notable effects on hatchability or initial weight.
Overall, incorporating Silybum marianum in their diet appears to help improve cholesterol levels and support overall growth in chickens.
Read More
9
We examined the effects of a polyherbal emulsion named F6-SMONSECCE on diabetic rats induced with alloxan. This formulation, crafted from various extracts, showed promising results in reducing blood sugar and cholesterol levels significantly.
Remarkably, we found reductions in total cholesterol and triglycerides, alongside improvements in insulin and HDL levels. The herbal treatment also promoted healing in the pancreas and kidneys, suggesting potential as a supportive remedy for diabetes and related conditions. However, further research is essential to fully understand its impact on human health.
Remarkably, we found reductions in total cholesterol and triglycerides, alongside improvements in insulin and HDL levels. The herbal treatment also promoted healing in the pancreas and kidneys, suggesting potential as a supportive remedy for diabetes and related conditions. However, further research is essential to fully understand its impact on human health.
Read More
Most Useful Reviews
8
Highly recommend
26 people found this helpful
I've consistently used this product for about a year with remarkable results for my family. I will definitely continue repurchasing it, and I highly recommend it to others. Thanks to iHerb for the rapid delivery and quality products.
Read More
9
Normalised cholesterol levels
1 people found this helpful
After taking glutathione and vitamin D-3, I felt more energetic, and my liver function values returned to normal after years of slight abnormalities. My hair loss has decreased, and my eGFR improved from 58 to 70 in three months. Notably, my HDL cholesterol increased from 64 to 78.
Read More
7.5
Liver health improved
1 people found this helpful
A good supplement for cleansing and detoxifying the body. I personally experienced high liver enzymes, and after taking glutathione, everything returned to an acceptable level. I would recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
- All Researches
9
Our investigation focused on the cardio-protective effects of Cocculus hirsutus (CH) in rats experiencing hypertension and high cholesterol. We pre-treated groups of rats with varying doses of CH before inducing hypertension through renal occlusion. Significant improvements were observed: CH lowered blood pressure, reduced harmful heart conditions, and improved cholesterol levels.
Additionally, the healthy structure of arterial layers and enhanced antioxidant levels suggested a overall protective benefit. This suggests that CH might be a promising natural option for cardiovascular health.
Additionally, the healthy structure of arterial layers and enhanced antioxidant levels suggested a overall protective benefit. This suggests that CH might be a promising natural option for cardiovascular health.
Read More
9
We examined the effects of a polyherbal emulsion named F6-SMONSECCE on diabetic rats induced with alloxan. This formulation, crafted from various extracts, showed promising results in reducing blood sugar and cholesterol levels significantly.
Remarkably, we found reductions in total cholesterol and triglycerides, alongside improvements in insulin and HDL levels. The herbal treatment also promoted healing in the pancreas and kidneys, suggesting potential as a supportive remedy for diabetes and related conditions. However, further research is essential to fully understand its impact on human health.
Remarkably, we found reductions in total cholesterol and triglycerides, alongside improvements in insulin and HDL levels. The herbal treatment also promoted healing in the pancreas and kidneys, suggesting potential as a supportive remedy for diabetes and related conditions. However, further research is essential to fully understand its impact on human health.
Read More
9
Silymarin positively influences cholesterol
We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.
Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.
However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.
Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.
However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.
Read More
9
Milk thistle reduces cholesterol levels
We evaluated the impact of milk thistle meal on cholesterol levels and overall health in laying hens. In an engaging trial with 200 hens, we explored four different levels of milk thistle (0%, 15%, 30%, and 60%) combined with varying energy levels over 80 days.
Our findings revealed that incorporating milk thistle significantly lowered serum cholesterol and triglycerides while boosting beneficial high-density lipoprotein (HDL) levels. The hens also showed improved feed conversion efficiency and reduced harmful bacterial counts, highlighting the potential health benefits of milk thistle in poultry diets.
Our findings revealed that incorporating milk thistle significantly lowered serum cholesterol and triglycerides while boosting beneficial high-density lipoprotein (HDL) levels. The hens also showed improved feed conversion efficiency and reduced harmful bacterial counts, highlighting the potential health benefits of milk thistle in poultry diets.
Read More
9
Combination treatment reduces cholesterol
We explored the effects of a nutraceutical blend containing silybum marianum, along with Berberis aristata and monacolin K, on cholesterol levels in patients with low cardiovascular risk.
In our study, 143 participants were involved in a randomized, double-blind, placebo-controlled trial over three months. The results revealed a significant decrease in total cholesterol, triglycerides, and LDL cholesterol with the combination treatment.
While there were positive changes, the study suggests that this blend of ingredients is not only effective for reducing cholesterol but also safe.
In our study, 143 participants were involved in a randomized, double-blind, placebo-controlled trial over three months. The results revealed a significant decrease in total cholesterol, triglycerides, and LDL cholesterol with the combination treatment.
While there were positive changes, the study suggests that this blend of ingredients is not only effective for reducing cholesterol but also safe.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
8
Highly recommend
26 people found this helpful
I've consistently used this product for about a year with remarkable results for my family. I will definitely continue repurchasing it, and I highly recommend it to others. Thanks to iHerb for the rapid delivery and quality products.
Read More
9
Normalised cholesterol levels
1 people found this helpful
After taking glutathione and vitamin D-3, I felt more energetic, and my liver function values returned to normal after years of slight abnormalities. My hair loss has decreased, and my eGFR improved from 58 to 70 in three months. Notably, my HDL cholesterol increased from 64 to 78.
Read More
7.5
Liver health improved
1 people found this helpful
A good supplement for cleansing and detoxifying the body. I personally experienced high liver enzymes, and after taking glutathione, everything returned to an acceptable level. I would recommend it.
Read More
9
Significant skin lightening
2 people found this helpful
I have taken this antioxidant drink for the second time in two-month courses upon my nutritionist's recommendation. It should be consumed each morning, 30 minutes before breakfast, for optimal results. Due to high pigmentation after three pregnancies, I can already see significant improvements, aided by other vitamins. Additionally, Glutathione effectively cleanses my body. The price is excellent, and I highly recommend it!
Read More
7.5
Significant improvement
1 people found this helpful
I highly recommend the glutathione 500mg capsules. I've requested them several times as I've noticed considerable improvement in my condition. Being diabetic, this has helped me significantly.
Read More
Frequently Asked Questions
9
Normalised cholesterol levels
1 people found this helpful
After taking glutathione and vitamin D-3, I felt more energetic, and my liver function values returned to normal after years of slight abnormalities. My hair loss has decreased, and my eGFR improved from 58 to 70 in three months. Notably, my HDL cholesterol increased from 64 to 78.
7
Visible skin improvements
1 people found this helpful
This is my first experience with glutathione. The ingredient concentration is higher, and the price is lower than in Japan, so I decided to try it. The capsules are quite large, which makes them hard to swallow. By the third day, I noticed my skin had improved, looking a tone brighter, similar to the effects of a mask pack. I will continue using it because I've felt its benefits over the past month.
2
Limited effect
1 people found this helpful
I had great expectations for this product, but I didn't observe much difference, even with the added alpha lipoic acid and milk thistle. For me, NAC appears to be more effective in managing my high cholesterol.
7.5
Enhanced skin clarity
1 people found this helpful
Not only does it help decompose alcohol, but it also has a skin-whitening effect! Initially, I only took it after drinking, but now I use it alongside other skin-whitening supplements for improved daily liver function. I’ve noticed a clear improvement in my skin clarity. I typically take between 500 to 1000mg daily, increasing my dose around alcohol consumption.
9
Our investigation focused on the cardio-protective effects of Cocculus hirsutus (CH) in rats experiencing hypertension and high cholesterol. We pre-treated groups of rats with varying doses of CH before inducing hypertension through renal occlusion. Significant improvements were observed: CH lowered blood pressure, reduced harmful heart conditions, and improved cholesterol levels.
Additionally, the healthy structure of arterial layers and enhanced antioxidant levels suggested a overall protective benefit. This suggests that CH might be a promising natural option for cardiovascular health.
Additionally, the healthy structure of arterial layers and enhanced antioxidant levels suggested a overall protective benefit. This suggests that CH might be a promising natural option for cardiovascular health.
8
We evaluated how Grifola frondosa, a type of mushroom, affects cholesterol levels when fed to hamsters on a high-fat diet. Our findings revealed that the fruiting bodies of this mushroom helped reduce weight gain and lowered both serum triglycerides and cholesterol levels.
Additionally, specific extracts from the mushroom improved the antioxidant status, supporting better liver health. These results hint that Grifola frondosa might boost bile acid synthesis and help in managing high cholesterol effectively. However, it's important to note that further research is needed to confirm these benefits in humans.
Additionally, specific extracts from the mushroom improved the antioxidant status, supporting better liver health. These results hint that Grifola frondosa might boost bile acid synthesis and help in managing high cholesterol effectively. However, it's important to note that further research is needed to confirm these benefits in humans.
7
Silibinin shows mixed diabetes effects
We explored how silibinin, the key ingredient in milk thistle, impacts diabetes and its complications. This review examined a variety of studies and highlighted that silibinin showed promise in improving diabetes by reducing blood sugar levels and lowering cholesterol and triglycerides.
It seems silibinin enhances overall metabolic health by lowering insulin resistance and decreasing inflammation. However, while the findings are encouraging, we must acknowledge that more comprehensive research is needed to unravel the specific mechanisms at play.
It seems silibinin enhances overall metabolic health by lowering insulin resistance and decreasing inflammation. However, while the findings are encouraging, we must acknowledge that more comprehensive research is needed to unravel the specific mechanisms at play.
9
Combination treatment reduces cholesterol
We explored the effects of a nutraceutical blend containing silybum marianum, along with Berberis aristata and monacolin K, on cholesterol levels in patients with low cardiovascular risk.
In our study, 143 participants were involved in a randomized, double-blind, placebo-controlled trial over three months. The results revealed a significant decrease in total cholesterol, triglycerides, and LDL cholesterol with the combination treatment.
While there were positive changes, the study suggests that this blend of ingredients is not only effective for reducing cholesterol but also safe.
In our study, 143 participants were involved in a randomized, double-blind, placebo-controlled trial over three months. The results revealed a significant decrease in total cholesterol, triglycerides, and LDL cholesterol with the combination treatment.
While there were positive changes, the study suggests that this blend of ingredients is not only effective for reducing cholesterol but also safe.
8
Berberol(®) enhances cholesterol management
We investigated the effectiveness of a combination of berberine and silymarin (Berberol(®)) in patients with high cholesterol who cannot tolerate statins.
Our study included type 2 diabetic patients who previously reduced their statin doses or chose alternative treatments.
We found that Berberol(®) significantly lowered triglycerides and LDL cholesterol, alongside fasting blood glucose levels, without causing toxicity.
This suggests that Berberol(®) can serve as a safe and effective option for managing lipid and blood sugar levels in these patients.
Our study included type 2 diabetic patients who previously reduced their statin doses or chose alternative treatments.
We found that Berberol(®) significantly lowered triglycerides and LDL cholesterol, alongside fasting blood glucose levels, without causing toxicity.
This suggests that Berberol(®) can serve as a safe and effective option for managing lipid and blood sugar levels in these patients.
9
Silymarin positively influences cholesterol
We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.
Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.
However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.
Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.
However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.
References
- Gunjegaonkar SM, Khakal VR, Joshi AA, Nargund SL, Shinde SD, et al. Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats. J Ayurveda Integr Med. 2022;13:100652. doi:10.1016/j.jaim.2022.100652
- Wu WT, Hsu TH, Chen WL, Yang CK, Lo HC. Polysaccharides of Grifola frondosa ameliorate oxidative stress and hypercholesterolaemia in hamsters fed a high-fat, high-cholesterol diet. J Pharm Pharmacol. 2022;74:1296. doi:10.1093/jpp/rgac031
- Spim SRV, Pistila AMH, Pickler TB, Silva MT, Grotto D. Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. Int J Med Mushrooms. 2021;23:1. doi:10.1615/IntJMedMushrooms.2021038773
- Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x
- Akhtar MT, Almas T, Safdar S, Saadia M, Qadir R, et al. Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats. ACS Omega. 2023;8:21642. doi:10.1021/acsomega.3c01027
- Zhu Y, Zhang X, Du P, Wang Z, Luo P, et al. Dietary herbaceous mixture supplementation reduced hepatic lipid deposition and improved hepatic health status in post-peak laying hens. Poult Sci. 2022;101:101870. doi:10.1016/j.psj.2022.101870
- Çeribaşı S, Türk G, Özçelik M, Doğan G, Çeribaşı AO, et al. Negative effect of feeding with high energy diets on testes and metabolic blood parameters of male Japanese quails, and positive role of milk thistle seed. Theriogenology. 2020;144:74. doi:10.1016/j.theriogenology.2019.12.021
- Tóth B, Németh D, Soós A, Hegyi P, Pham-Dobor G, et al. The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on Dyslipidaemia - A Meta-analysis and Systematic Review. Planta Med. 2020;86:132. doi:10.1055/a-1063-1649
- Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39. doi:10.1016/j.phymed.2018.03.050
- Hashemi Jabali NS, Mahdavi AH, Ansari Mahyari S, Sedghi M, Akbari Moghaddam Kakhki R. Effects of milk thistle meal on performance, ileal bacterial enumeration, jejunal morphology and blood lipid peroxidation in laying hens fed diets with different levels of metabolizable energy. J Anim Physiol Anim Nutr (Berl). 2018;102:410. doi:10.1111/jpn.12747
- Derosa G, D'Angelo A, Romano D, Maffioli P. Effects of a Combination of Berberis aristata, Silybum marianum and Monacolin on Lipid Profile in Subjects at Low Cardiovascular Risk; A Double-Blind, Randomized, Placebo-Controlled Trial. Int J Mol Sci. 2017;18. doi:10.3390/ijms18020343
- Ni X, Wang H. Silymarin attenuated hepatic steatosis through regulation of lipid metabolism and oxidative stress in a mouse model of nonalcoholic fatty liver disease (NAFLD). Am J Transl Res. 2016;8:1073.
- Morovat M, Chamani M, Zarei A, Sadeghi AA. Dietary but not in ovo feeding of Silybum marianum extract resulted in an improvement in performance, immunity and carcass characteristics and decreased the adverse effects of high temperatures in broilers. Br Poult Sci. 2016;57:105. doi:10.1080/00071668.2015.1121537
- Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:89. doi:10.2147/DMSO.S78877
- Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses. Atherosclerosis. 2015;239:87. doi:10.1016/j.atherosclerosis.2014.12.043
- Derosa G, Bonaventura A, Bianchi L, Romano D, D'Angelo A, et al. Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients. Expert Opin Biol Ther. 2013;13:1495. doi:10.1517/14712598.2013.832751
- Cacciapuoti F, Scognamiglio A, Palumbo R, Forte R, Cacciapuoti F. Silymarin in non alcoholic fatty liver disease. World J Hepatol. 2013;5:109. doi:10.4254/wjh.v5.i3.109
- Skottová N, Kazdová L, Oliyarnyk O, Vecera R, Sobolová L, et al. Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats. Pharmacol Res. 2004;50:123.
- Skottová N, Krecman V, Walterová D, Ulrichová J, Kosina P, et al. Effect of silymarin on serum cholesterol levels in rats. Acta Univ Palacki Olomuc Fac Med. 1998;141:87.
